Unproven, non-validated, diagnostic tests are also discussed. Skin prick testing remains the first line approach in most instances the added value of serum specific IgE to whole allergen extracts or components, as well as the role of basophil activation tests, is evaluated. It discusses skin tests, challenges, and serological and cellular in vitro tests, and provides an overview of indications, advantages and disadvantages of each in conditions such as respiratory, food, venom, drug, and occupational allergy. This review provides a thorough and updated critical appraisal of the most frequently used diagnostic tests, both in vivo and in vitro. Wood, MD, bb and Torsten Zuberbier, MD, PhD bcĬurrently, testing for immunoglobulin E (IgE) sensitization is the cornerstone of diagnostic evaluation in suspected allergic conditions. Tang, MBBS, PHD, aw Bernard Yu-Hor Thong, MD, ax Rudolf Valenta, MD, ay, az, ba Robert A. Sánchez Borges, MD, as Enrico Scala, MD, at Gian-Enrico Senna, MD, au Juan Carlos Sisul, MD, av Mimi L.K. Rosário Filho, MD, PhD, aq Lanny Rosenwasser, MD, ar Mario A. Poulsen, PhD, am Ruby Pawankar, MD, PhD, an Harald E. Ledford, MD, ai Olga Patricia Monge Ortega, MD, aj Mário Morais Almeida, MD, ak Oliver Pfaar, MD, PhD, al Lars K. DuBuske, MD, z Marta Ferrer Puga, MD, aa Roy Gerth van Wijk, MD, PhD, ab Sandra Nora González Díaz, MD, PhD, ac Alexei Gonzalez-Estrada, MD, ad Edgardo Jares, MD, ae Ayse Füsun Kalpaklioğlu, MD, af Luciana Kase Tanno, MD, PhD, ag Marek L.

Bousquet, MD, PhD, q, r, s, t, u Victoria Cardona, MD, PhD, v Wen Chin Chiang, MBBS, w Pascal M. Fischer, MD, n, 1 Tari Haahtela, MD, o Martti Antila, MD, p Jean J. Oppenheimer, MD, l, 1 Erika Jensen-Jarolim, MD, m, 1 David A. Maximiliano Gómez, MD, PhD, j, 1 Olga Luengo Sánchez, MD, PhD, k, 1 John J. Ansotegui, MD, PhD, a, 1, ∗ Giovanni Melioli, MD, b, 1 Giorgio Walter Canonica, MD, c, 1 Luis Caraballo, MD, PhD, d, 1 Elisa Villa, MD, PhD, e, 1 Motohiro Ebisawa, MD, PhD, f, 1 Giovanni Passalacqua, MD, g, 1 Eleonora Savi, MD, h, 1 Didier Ebo, MD, PhD, i, 1 R.

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